The Effect of Integrative Biopsychosocial Therapy on Comorbid Major Depressive Disorder and Posttraumatic Stress Disorder

Abstract

Addressing the critical need for holistic mental health interventions in the Philippines, this study evaluates Integrative Biopsychosocial Therapy for comorbid PTSD and depression using an experimental ABA single-subject reversal design. Results indicate the therapy is safe and effective; the female participant demonstrated stable vital signs and significant improvements in anxiety, mood, sleep, and cognitive functioning, though sustained support is required for continued PTSD management. These findings validate a proposed practitioner's pocket guide for culturally sensitive care while underscoring the need for future longitudinal research with larger, diverse samples to confirm generalizability and long-term efficacy.